Monday, March 16, 2009

Laser Gun : can kill the mosquitoes

Scientists in the U.S. are developing a laser gun that could kill millions of mosquitoes in minutes.The laser, which has been dubbed a "weapon of mosquito destruction" fires at mosquitoes once it detects the audio frequency created by the beating of its wings.

The laser beam then destroys the mosquito, burning it on the spot.Click here for more

Developed by some of the astrophysicists involved in what was known as the "Star Wars" anti-missile programs during the Cold War, the project is meant to prevent the spread of malaria.

Lead scientist on the project, Dr. Jordin Kare, told CNN that the laser would be able to sweep an area and "toast millions of mosquitoes in a few minutes."

Malaria is a life-threatening disease caused by parasites that are transmitted to people from the bites of female mosquitoes.t is particularly prevalent in tropical and sub-tropical regions of the world and kills an African child every 30 seconds, according to the World Health Organization.

There are an estimated 300 million acute cases of malaria each year globally, resulting in more than one million deaths, the WHO reports.

Responding to questions about any potential harm the laser could pose to the eco-system, Kare said: "There is no such thing as a good mosquito, there's nothing that feeds exclusively on them. No one would miss mosquitoes," he said.

"In any case," he added. "The laser is able to distinguish between mosquitoes that go after people and those that aren't dangerous."
He added that other insects would not be affected by the laser's beam.

The research was commissioned by Intellectual Ventures, a Washington, U.S.-based company that was founded by Nathan Myhrvold, a former Microsoft Corporation executive.

His previous boss, Bill Gates, who funded the research, asked Myhrvold to look into new ways of combating malaria.source:CNN

Saturday, March 14, 2009

Nepal : a photographic tour

to see more photos click here
THe best tourist destination .
Click here for more wonderful pictures
Country of natural beauty.

End of the 240 years of History of Monarchy .

Initialization of new era in Nepali history .


Living goddess "Kumari"


This reminds the 12 years long insurgency in Nepal.



Kathmandu; the city of Temples.

Political instability, which is very common in Nepal
.

Slums of Nepal.

In The day of color "Holi".

Friday, March 13, 2009

Cartoon time

laser

A laser is a source of light that emits the light ;a electromagnetic radiation through a process called stimulated emission. Lasers are highly useful sources in analytical instrumentation because of their high intensities, their narrow bandwidths, and the coherent nature of their outputs. The first laser was described in 1960. Since that thime chemists have found numerous useful application for these sources in high resolution spectroscopy .READ MORE
The word laser originated as an acronym for light amplification by stimulated emission of radiation. The word light in this phrase is used in the broader sense, referring to electromagnetic radiation of any frequency, not just that in the visible spectrum. Hence there are infrared lasers, ultraviolet lasers, X-ray lasers, etc. Because the microwave equivalent of the laser, the maser, was developed first, devices that emit microwave and radio frequencies are usually called masers. In early literature, particularly from researchers at Bell Telephone Laboratories, the laser was often called the optical maser. This usage has since become uncommon, and as of 1998 even Bell Labs uses the term laser.
The back-formed verb to lase means "to produce laser light" or "to apply laser light to". The word "laser" is sometimes used to describe other non-light technologies. For example, a source of atoms in a coherent state is called an "atom laser".
Chemical lasers

Chemical lasers are powered by a chemical reaction, and can achieve high powers in continuous operation. For example, in the Hydrogen fluoride laser (2700-2900 nm) and the Deuterium fluoride laser (3800 nm) the reaction is the combination of hydrogen or deuterium gas with combustion products of ethylene in nitrogen trifluoride. They were invented by George C. Pimentel.

C.V Raman


Chandrashekhara Venkata Raman (C.V.Rama) is a physicist and nobel laureate in Physics in 1930 for his work on "Raman Effect",Scattering of light. Raman entered Presidency College, Madras, in 1902, and in 1904 gained his B.Sc., winning the first place and the gold medal in physics. In 1907 he gained his M.Sc., obtaining the highest distinctions. He joined the Indian Finance Department as an Assistant Accountant General in Calcutta.February 28, 1928, through his experiments on the scattering of light, he discovered the Raman effect.Read more

On It was instantly clear that this discovery was an important one. It gave further proof of the quantum nature of light. Raman spectroscopy came to be based on this phenomenon. Rutherford referred to it his presidential address to the Royal Society in 1929. Raman was president of the 16th session of the Indian Science Congress in 1929. He was conferred a knighthood, and medals and honorary doctorates by various universities. Raman was confident of winning the Nobel Prize in Physics as well, and was disappointed when the Nobel Prize went to Richardson in 1928 and to de Broglie in 1929. He was so confident of winning the prize in 1930 that he booked tickets in July, even though the awards were to be announced in November, and would scan each day's newspaper for announcement of the prize, tossing it away if it did not carry the news. He did eventually win the 1930 Nobel Prize in Physics "for his work on the scattering of light and for the discovery of the effect named after him". He was the first Asian and first non-White to get any Nobel Prize in Science. Before him Gurudev Rabindranath Tagore (also Indian) had received the Nobel Prize for Literature.In 1954 he was awarded the Bharat Ratna. He was also awarded the Lenin Peace Prize in 1957.
India celebrates National Science Day on 28 February of every year to commemorate the discovery of the Raman effect in 1928

Hollow-Cathode Lamp


The one of the most common source for atomic absorption measurements is the hollow cathode lamp. Usually these kind of lamps consists of a tungsten anode and a cylindrical cathode sealed in a glass tube filled with neon or argon at the pressure of 1 to 5 torr. The cathode is constructed of the metal whose spectrum is desired or serves to support a layer of that metal .
Ionization occurs when a potential difference on the order of 300V is applied across the electrodes. The efficiency of the hollow cathode lamp depends on its geometry and the operating voltage. High voltages,and thus high currents, leads to greater intensities . READ MORE

This advantage is offset somewhat by an increase in Doppler broadening of the emission lines from the lamp. Hollow-cathode lamps are often used as source in AFS. In this application the lamps are pulsed with a duty cycle of 1% to 10% and peak current of 0.1 to 1 A, which increase their peak radiance by a factor of 10 to 100 relative to the steady state radiance of DC operation . A variety of hollow cathode lamps is available commercially . The cathodes of some consists of a mixture of several metals ;such lamps permit the determination fo more than a single element.see more in wikipedia

Thursday, March 12, 2009

X-ray Spectrometry


What is X-ray?
X-rays are short-wavelength electromagnetic radiation by the deceleration of high-energy electrons or by electronic transitions of electrons in the inner orbitals or atoms.The wavelength range of X-rays is from about 10e-5A to 100A;conventional X-ray spectroscopy is,however ,highly confined to the region of about 0.1A to 25A (1A=0.1nm=10e-10).
Emission of X-rays
For analytical purposes,X-rays are generated in four ways. 1.by bombardment of a metal target with a beam of high energy electrons ,2) by exposure of a substance to a primary beam of X-rays to generate a secondary beam of X-ray fluorescence,3)by use of a radioactive source whose decay process results in X-ray emissions,and 4)from a synchrotron radiation source. Only limited laboratory in US allows to produce X rays from synchrotron radiation.Contd.
Type rest of the post here

Monday, March 9, 2009

How To Send SMS without any Cost?

Have you ever thought that sending the SMS without any cost? Do you really think it is possible ?
Yes ! you can send the SMS to your friend without paying any money to corresponding phone company in United States. Just open your web browser , sign in your any email and you need to type the receiver cell no. followed by the email address of corresponding mobile company service providers.This is only for mobile companies with in the United States. CLICK HERE FOR MORE

T-Mobile: phonenumber@tmomail.net
Virgin Mobile: phonenumber@vmobl.com
Cingular: phonenumber@cingularme.com
Sprint: phonenumber@messaging.sprintpcs.com
Verizon: phonenumber@vtext.com
Nextel: phonenumber@messaging.nextel.com

Where phonenumber corresponds to the receiver cell number.

OK Have fun by sending the SMS to your friends,loved one without paying any money.

Sunday, March 8, 2009

Einstein Brain : What is the difference?


People like you and I, though mortal of course like everyone else, do not grow old no matter how long we live…[We] never cease to stand like curious children before the great mystery into which we were born.”

Albert Einstein

One sign of the lack of faith in the future progress of technology and the poor acceptance of the neurological basis for mind is the way in which our society treats the “post-mortem” human brain.

In some cases, the brains of those whom modern medicine cannot help are removed after cardiopulmonary arrest and donated (by the permission of the patient or the family) CLICK HERE TO READ MORE fo


for research. In such cases, the brains are preserved so they can be studied over a long period of time. They are also sectioned and prepared in other ways for examination. Such donated brains have helped scientists learn about the human brain, with an eye to improving methods for treating conditions such as Alzheimer’s or mental illness. However, other brains have been preserved mainly because they belonged to famous people.

One of the more famous cases is the brain of Albert Einstein, removed in 1955 and preserved apparently without his or his family’s permission, and then made available for study. According to an NPR report, Einstein’s brain was fixed, sectioned into over 200 blocks, embedded in celloidin, and then stored in formalin.

Since that time, Einstein’s brain has been further sectioned and divided among researchers. A 1985 study by Diamond et al. reported that the Einstein brain sections’ neurons were still observable, and the study’s authors even assumed the number of neurons preserved in Einstein’s brain would be the same as those in recent preserved brains.

Presumably, people have wanted to study the brains of famous people in order to learn something about what made those people special. Turning a person into a mere object of study is a questionable notion, though, and the idea that the study could yield any information about the person’s mind underscores how it is widely accepted by scientists that the brain instantiates the mind, and thus the person.

Neuroscience is still too much in its infancy to make much sense of the evidence of the brain, as the scientific reception to the Diamond study showed. We do not yet know how to “read” the brain for the specific memories and personality traits and other phenomena of mind stored in it. However, because we do know enough now to know that the mind arises from the brain, we must realize that to preserve the brain is to preserve the potential of mind, and to preserve the potential of mind is to preserve the possibility of life for the person whose brain it was.

The neural basis of personhood sits ill with older notions such as immaterial souls or spirits. The neural basis of personhood also fits poorly with existing medical and public policies such as commonly accepted definitions of death and laws related to end of life. If death is understood as irreversible damage to certain identity-critical areas of the brain, the irreversibility of such damage is put into question by every advance in the treatment of injury and disease of the brain, as well as by the brain’s mysterious ability to recover from conditions such as minimally conscious state after many years. The cardiopulmonary-arrest definition of death does not involve the condition of the brain, and the usual definitions of brain-death do not distinguish between identity-critical areas or aspects of the brain and other areas or aspects of the brain. A more rigorous definition of personal death has been developed by Ralph Merkle, who states:

“A person is dead according to the information-theoretic criterion if their memories, personality, hopes, dreams, etc. have been destroyed in the information-theoretic sense. That is, if the structures in the brain that encode memory and personality have been so disrupted that it is no longer possible in principle to restore them to an appropriate functional state then the person is dead. If the structures that encode memory and personality are sufficiently intact that inference of the memory and personality are feasible in principle, and therefore restoration to an appropriate functional state is likewise feasible in principle, then the person is not dead.”

Although there is still some lack of clarity about the “etc.” and “appropriate functional state”, this definition of death at least is founded on the neural basis of personhood. Those who believe in the future progress of technology and accept the neural basis of personhood are led inevitably to understand that preserving the brain is preserving the person, potentially for later resuscitation.

It is not impossible to imagine that, in a more advanced future time, the formalin-fixed, celloidin-embedded brain sections could be reassambled, and if the synaptic circuitry of the neurons were well preserved, any significant damage could be repaired. The brain might be able to be returned to a viable state by reversal of the fixation and removal of the celloidin embedding. Resuscitation of an isolated brain would be unacceptable, but eventually it might be possible to restore the rest of the body around the brain by cloning or regeneration of the cells or some other prosthetic embodiment.

As amazing as it may seem, a patient reduced to a preserved brain, whose mind would be in a stopped state, might be able to be healed, that is, totally restored to a healthy body and a mind which could resume the life it left off, with all the memories and personality intact.

The case of Albert Einstein’s brain is unfortunate. All the impudent cutting, handing around, and tampering with Einstein’s brains sections, and the crude preservation method, may have irreversibly damaged the neural basis of his personhood. Yet we do not know enough today about the brain to know how much of it needs to be preserved, and in what state, to be able to revive a person with future technology. The preservation of the brain, though, would provide a theoretical possibility of future resuscitation. It may not be possible to someday restore Albert Einstein from the remains of his brain, but if it were possible, those in possession of the brain sections would first have to be willing to consider whether their “specimens” might be the restorable fragments of a still potentially living person who deserves to live more than to be studied.

Top 10 reasons to smile : )

Smiling is a great way to make yourself stand out while helping your body to function better. Smile to improve your health, your stress level, and your attractiveness. Smiling is just one fun way to live longer read about the others and try as many as you can.

Note: Stay up-to-date on longevity and anti-aging with my weekly newsletter.

1. Smiling Makes Us Attractive
We are drawn to people who smile. There is an attraction factor. We want to know a smiling person and figure out what is so good. Frowns, scowls and grimaces all push people away -- but a smile draws them in.
2. Smiling Changes Our Mood
Next time you are feeling down, try putting on a smile. There's a good chance you mood will change for the better. Smiling can trick the body into helping you change your mood.
3. Smiling Is Contagious
When someone is smiling they lighten up the room, change the moods of others, and make things happier. A smiling person brings happiness with them. Smile lots and you will draw people to you.CLICK HERE FOR MORE REASONS

4. Smiling Relieves Stress
Stress can really show up in our faces. Smiling helps to prevent us from looking tired, worn down, and overwhelmed. When you are stressed, take time to put on a smile. The stress should be reduced and you'll be better able to take action.
5. Smiling Boosts Your Immune System
Smiling helps the immune system to work better. When you smile, immune function improves possibly because you are more relaxed. Prevent the flu and colds by smiling.
6. Smiling Lowers Your Blood Pressure
When you smile, there is a measurable reduction in your blood pressure. Give it a try if you have a blood pressure monitor at home. Sit for a few minutes, take a reading. Then smile for a minute and take another reading while still smiling. Do you notice a difference?
7. Smiling Releases Endorphins, Natural Pain Killers and Serotonin
Studies have shown that smiling releases endorphins, natural pain killers, and serotonin. Together these three make us feel good. Smiling is a natural drug.
8. Smiling Lifts the Face and Makes You Look Younger
The muscles we use to smile lift the face, making a person appear younger. Don't go for a face lift, just try smiling your way through the day -- you'll look younger and feel better.
9. Smiling Makes You Seem Successful
Smiling people appear more confident, are more likely to be promoted, and more likely to be approached. Put on a smile at meetings and appointments and people will react to you differently.
10. Smiling Helps You Stay Positive
Try this test: Smile. Now try to think of something negative without losing the smile. It's hard. When we smile our body is sending the rest of us a message that "Life is Good!" Stay away from depression, stress and worry by smiling.

Bisphenol A (BPA) : what is it? Q and A


Bisphenol A, commonly abbreviated as BPA, is an organic compound with two phenol functional groups. It is a difunctional building block of several important plastics and plastic additives. With an annual production of 2–3 million metric tonnes, it is an importantmonomer in the production of polycarbonate.

Suspected of being hazardous to humans since the 1930s, concerns about the use of bisphenol A in consumer products grabbed headlines in 2008 when several governments issued reports questioning its safety, and some retailers pulled products made from it off their shelves.Click here for more...


What is BPA?

Bisphenol A (BPA) is an industrial chemical used to make polycarbonate plastic resins, epoxy resins, and other products.


How is BPA used?

Bisphenol A (BPA) is a chemical building block that is used primarily to make polycarbonate plastic and epoxy resins. Polycarbonate plastic is a lightweight, high-performance plastic that possesses a unique balance of toughness, optical clarity, high heat resistance, and excellent electrical resistance. Because of these attributes, polycarbonate is used in a wide variety of common products including digital media (e.g., CDs, DVDs), electrical and electronic equipment, automobiles, sports safety equipment, reusable food anddrink containers , and many other products.

BPA is also used in the production of epoxy resins. Epoxy resins have many uses including engineering applications such as electrical laminates for printed circuit boards, composites, paints and adhesives, as well as in a variety of protective coatings. Cured epoxy resins are inert materials used as protective liners in metal cans to maintain the quality of canned foods and beverages, and have achieved wide acceptance for use as protective coatings because of their exceptional combination of toughness, adhesion, formability, and chemical resistance.

How much BPA is produced?

In 2002, approximately 2.8 million tons of bisphenol A (BPA) was produced globally (Source: Chemical Market Associates, Inc. (CMAI)). Most BPA is used to make polycarbonate plastic and epoxy resins.

Has BPA been tested for safety?

Yes. Bisphenol A (BPA) is one of the most extensively tested materials in use today. BPA has been safely used in consumer products and researched and studied for over 40 years. The weight of scientific evidence clearly supports the safety of BPA and provides strong reassurance that there is no basis for human health concerns from exposure to BPA.

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Does BPA pose a risk to human health?

Safety assessments of bisphenol A (BPA) conclude that the potential human exposure to BPA from polycarbonate plastics and epoxy resins is more than 400 times lower than the safe level of BPA set by the U.S. Environmental Protection Agency. This minimal level of exposure to BPA poses no known risk to human health.

The use of polycarbonate plastic and epoxy resins for food contact applications has been and continues to be recognized as safe by the U.S. Food and Drug Administration, the European Commission's Scientific Committee on Food, the United Kingdom Food Standards Agency, and otherregulatory agencies worldwide.

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Am I exposed to BPA from polycarbonate plastics?

Researchers from government agencies, academia, and industry worldwide have studied the potential for bisphenol A (BPA) to migrate from polycarbonate products into foods and beverages. These studies consistently show that the potential migration of BPA into food is extremely low, generally less than 5 parts per billion under conditions typical for uses of polycarbonate products. At this level, a consumer would have to ingest more than 1,300 pounds of food and beverages in contact with polycarbonate every day for an entire lifetime to exceed the safe level of BPA set by the U.S. Environmental Protection Agency. Consequently, human exposure to BPA from polycarbonate plastics is minimal and poses no known health risk.

The use of polycarbonate plastic for food contact applications continues to be recognized as safe by the U.S. Food and Drug Administration, the European Commission Scientific Committee on Food, the United Kingdom Food Standards Agency, the Japan Ministry for Health and Welfare and other regulatory authorities worldwide.

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Am I exposed to BPA from can linings?

Government and industry researchers have reported that bisphenol A (BPA) is generally not detected in canned beverages and only extremely low levels (generally less than 37 parts per billion) of BPA have been reported to migrate into some canned foods. At these levels, a consumer would have to ingest more than 500 pounds of canned food and beverages every day for an entire lifetime to exceed the safe level of BPA set by the U.S. Environmental Protection Agency. Consequently, human exposure to BPA from can coatings is minimal and poses no known health risk.

Can coatings continue to be recognized as safe by the U.S. Food and Drug Administration, the U.K. Food Standards Agency, the EU Scientific Committee on Food and other government bodies worldwide.

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Does BPA leach out of dental sealants?

Several studies have reported that trace levels of bisphenol A (BPA) may be released from certain dental sealants, but only during a short time period immediately after application of the sealant. In addition, the highest level of BPA exposure reported from dental sealants is more than 50,000 times lower than levels shown to cause toxicity in animal studies. Based on these findings, human exposure to BPA fromdental sealants is minimal and poses no known health risk.

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What about claims that very low-dose exposure to BPA has resulted in reproductive effects in laboratory animals?

The low-dose hypothesis for bisphenol A (BPA) has been thoroughly tested with a series of comprehensive, carefully conducted studies. This research includes definitive large-scale studies as well as studies aimed at replicating the results of studies reporting low-dose effects. The consistent lack of low-dose effects found in these studies demonstrates that the low-dose hypothesis is not valid.

The weight of scientific evidence clearly supports the safety of BPA and provides strong reassurance that there is no basis for human health concerns from exposure to low doses of BPA.

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Is BPA used in pesticides?

No. According to U.S. Environmental Protection Agency records, bisphenol A (BPA) has not been used as an inert ingredient in pesticide products in the U.S. since at least 1994. BPA's status as an (inert) pesticide ingredient was recently rescinded by EPA, according to the June 11, 1999 Federal Register. According to the notice, BPA was removed from a listing of approved inert substances because it was not in use as an additive.

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Is BPA found in the environment?

Although the vast majority of bisphenol A (BPA) is converted at manufacturing sites into products, low-level releases of BPA to the environment are possible. Government researchers have reported that, when detected at all, BPA is found in water at levels generally well below 1 part per billion.

Extensive testing and environmental monitoring shows that BPA is rapidly biodegraded in the environment. The weight of scientific evidence shows that the trace amounts of BPA that are sometimes detected in waterways pose no risk to the environment.

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Does BPA adversely impact aquatic organisms?

The weight of evidence from numerous validated studies demonstrates the trace levels of BPA that have been detected in the environment are far below the level at which adverse effects on aquatic organisms would be expected. Bisphenol A (BPA) does not accumulate in aquatic organisms to any appreciable extent and is not classified as bioaccumulative by the U.S. Environmental Protection Agency.

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Is there an alternative to BPA in consumer products?

Bisphenol A (BPA) is used primarily to make polycarbonate plastic and epoxy resins, and is integral to the manufacture of both materials. Both polycarbonate and epoxy are unique and versatile materials that out-perform other materials in a broad range of end-uses providing consumers with a unique range of properties not available in other materials. Polycarbonate plastic is a lightweight, high-performance plastic that possesses a unique balance of toughness, optical clarity, high heat resistance, and excellent electrical resistance that make it ideal for a wide variety of applications. Epoxy resins are inert materials that have achieved wide acceptance for use as protective coatings and other applications because of their exceptional combination of toughness, adhesion, formability, and chemical resistance. Epoxy can coatings are essential to protecting food and beverages from contamination.

BPA is one of the most extensively tested materials in use today; its safety has been studied for more than 40 years. The extensive safety data that exist for BPA show that consumer products made with BPA are safe for their intended use and pose no known risks to human health. The U.S. FDA and international agencies charged to protect public health fully support the use of these materials.

Saturday, March 7, 2009

How to know the traffic rank of the blog,website?

Most people who has their blog or website ,sometimes they want to know the traffic rank or website rank in entire web universe. There is the site that gives you the exact rank ,hits,most popular website by countries, rank of visiting countries of any website or blog. Alexa the web Information system or click here for more information

Chemical and Physical properties Used in Instrumental Methods


Characteristic Properties                And                              Instrumental methods 

Emission of radiation   
Emissionspectroscop(X-ray,Uv,visible,electron,Auger);flourescence, phosphorescence,and luminescence (X-ray,Uv,and visible)   

Absorption fo radiation

Spectrophotometry and photometry (X-ray,UV visble IR); Photoacoustic spectroscopy nuclear magnetic resonance and electron spin resonance spectroscopy

Scattering of radiation                   Turbidimetry;nephelometry;Raman Spectroscopy
                                           
Diffraction of radiation                   X-ray and electron diffracton methods

Refraction of radiation                    Refractometry;interferometry

Rotation of radiation
Polarimetry;optical rotary dispersion;circular dichroism

Electrical potential 
Potentialmetry; optical rotary dispersion ;circular dichroism

Electrical charge                            Columetry

Electrical current                          Amperometry;polarography

Electrical resistance                    Conductometry

Mass                                                    Gravimetry(quartz crystal microbalance)

Mass-to-charge ratio Mass spectrometry

Rate of reaction  Kinetic methods

Thermal characteristics         
Thermal gravimetry and titrimetry;differntial scanning calorimetry;differntial thermal analysis ;thermal conductometric methods

Radioactivity                                  Activation and isotope dilution methods                  

Carbamazepine : Mood Stablizing drug


Carbamazepine (CBZ) is an anticonvulsant and mood stabilizing drug used primarily in the treatment of epilepsy and bipolar disorder. It is also used to treat ADD, ADHD, schizophrenia, phantom limb syndrome, paroxysmal extreme pain disorder, and trigeminal neuralgia.
Trade names

Carbamazepine has been sold under the names Tegretol, Biston, Calepsin, Carbatrol, Epitol, Equetro, Finlepsin, Sirtal, Stazepine, Telesmin,Teril, Timonil, Trimonil, Epimaz, Carbama/Carbamaze (in New Zealand), Amizepin( in Poland ), Hermolepsin (Sweden) and Degranol (in South Africa)READ MORE POST

History

Carbamazepine was discovered by chemist Walter Schindler at J.R. Geigy AG (now part of Novartis) in Basel, Switzerland, in 1953.[2] Schindler then synthesized the drug in 1960, before its anti-epileptic properties had been discovered.
Carbamazepine was first marketed as a drug to treat trigeminal neuralgia in 1962. It has been used as an anticonvulsant in the UK since 1965, but only approved in the U.S. since 1974.
In 1971, Drs. Takezaki and Hanaoka first used carbamazepine to control mania in patients refractory to antipsychotics (lithium was not available in Japan at that time). Dr. Okuma, working independently, did the same thing with success. As they were also epileptologists, they had some familiarity with the anti-aggression effects of this drug. Carbamazepine would be studied for bipolar disorder throughout the 1970s.[3]
[edit]Adverse effects

Carbamazepine is known to render many hormonal contraception products ineffective, due to its action as a cytochrome P450 enzyme inducer, which is the system that metabolizes many oral contraceptives. Carbamazepine causes more cytochrome P450 enzyme to be produced, which hastens removal of the contraceptive from the blood plasma although the clinical significance of this effect is debatable.
Common side effects include drowsiness, headaches and migraines, motor coordination impairment and/or upset stomach. Carbamazepine preparations typically greatly decrease a person's alcohol tolerance.
Less common side effects include cardiac arrhythmias, blurry or double vision and/or the temporary loss of blood cells or platelets and in rare cases can cause aplastic anemia. With normal use, small reductions in white cell count and serum sodium are common, however, in rare cases, the loss of platelets may become life-threatening. This occurs commonly enough that a doctor may recommend frequent blood tests during the first few months of use, followed by three to four tests per year for established patients. In the UK, testing is generally performed much less frequently for long-term carbamazepine patients--typically once per year. Additionally, carbamazepine may exacerbate preexisting cases of hypothyroidism, so yearly thyroid function tests are advisable for persons taking the drug.
There are also reports of an auditory side effect for carbamazepine use, whereby patients perceive sounds about a semitone lower than their actual pitch.[4] Thus, middle C would be heard as the note B3 just below it, etc. This unusual side-effect is usually not noticed by most people, and quickly disappears after the person stops taking carbamazepine.
Oxcarbazepine, a derivative of carbamazepine, reportedly has fewer and less serious side effects.
Carbamazepine may cause Syndrome of inappropriate antidiuretic hormone, since it both increases the release and potentiates the action of ADH (vasopressin).
Carbamazepine may aggravate juvenile myoclonic epilepsy, so it is important to mention any history of jerking, especially in the morning, before starting to take this drug.
Pregnant women taking carbamazepine put their fetuses at increased risk for teratogenic effects. As a result, they should be given folic acid supplementation and undergo prenatal ultrasonography for diagnosis.
In addition, carbamazepine has been linked to serious adverse cognitive anomalies, including EEG slowing[5] and cell apoptosis.[6]
The FDA informed health care professionals that dangerous or even fatal skin reactions (Stevens Johnson syndrome and toxic epidermal necrolysis), that can be caused by carbamazepine therapy, are significantly more common in patients with a particular human leukocyte antigen (HLA) allele, HLA-B*1502. This allele occurs almost exclusively in patients with ancestry across broad areas of Asia, including South Asian Indians. [7] In Europeans a large proportion of sensitivity is associated with HLA-B58.
[edit]Mechanism of action

The mechanism of action of carbamazepine and its derivatives is relatively well understood. Voltage-gated sodium channels are the molecular pores that allow brain cells (neurons) to generate action potentials, the electrical events that allow neurons to communicate over long distances. After the sodium channels open to start the action potential, they inactivate, essentially closing the channel. Carbamazepine stabilizes the inactivated state of sodium channels, meaning that fewer of these channels are available to open, making brain cells less excitable (less likely to fire).
[edit]Interactions

Valproic acid and valnoctamide both interact with carbamazepine, as they inhibit microsomal epoxide hydrolase (mEH), the enzyme responsible for the breakdown of carbamazepine-10,11 epoxide into inactive metabolites.[8] By inhibiting mEH, valproic acid and valnoctamide cause a buildup of the active metabolite, prolonging the effects of carbamazepine and delaying its excretion.
Carbamazepine interacts with multiple drugs and caution should be used in combining other medicines with it. Lower levels of carbamazepine are seen when administrated with phenobarbital, phenytoin (Dilantin), or primidone (Mysoline). Carbamazepine, as CYP 450 inducer, may increase clearance of many drugs, decreasing their blood levels.[9] Drugs that are more rapidly metabolized with carbamazepine include warfarin (Coumadin), phenytoin (Dilantin), theophylline, and valproic acid (Depakote, Depakote ER, Depakene, Depacon).[citation needed] Carbamazepine levels are elevated when taken with erythromycin, cimetidine (Tagamet), propoxyphene (Darvon), and calcium channel blockers.[citation needed] Carbamazepine also increases the metabolism (destruction) of the hormones in birth control pills and can reduce their effectiveness, potentially leading to unexpected pregnancies.REF:WIKIPEDIA

How to split the post in blogger

Your blog's main page usually shows the entire content of each post. If your posts are usually more than 2 paragraphs, then your visitor will find it difficult to quickly find the topic of interest to him because he needs to scroll down a lot. This is where expandable post summaries helped in the old Blogger. This hack serves the same purpose for the new Blogger and more! That is, main page will show only post summaries and when you click "Read more", the full post appears in the main page itself (Peekaboo view)!! I got some requests to do such a hack and I managed to get it working. Later, Hans improved it by adding a "Summary only" link with which you can collapse the post back to summary. Together, we also made the "Read more" link to show up only for the posts that have a summary. This is an amazing hack but you need to be careful while changing your template. If you are not familiar with HTML, I strongly suggest you to get help from somebody who knows HTML while applying this hack. Here are the steps to follow. Click here for more


Step 0: Download and save your template so that you can go back to it if there is any problem with this hack (Important!)
Step 1: Find the tag in your template and add this line before it (if you have not already done so).



Step 2: Find the includable called 'post' and copy/paste the changes highlighted in red in this page (Be very careful and avoid mistakes. Note that the word "uncustomized-post-template" may not appear in your template but that's fine.). To find the includable, you could search for the term id='post'. If you are not able to find it, you may not have expanded the template. Select the checkbox named "Expand Widget Templates", which is right above the template code, to expand it into more code.
Step 3. Goto Settings->Formatting and at the bottom, you will find the text box provided to specify the "Post template". Copy/paste these lines into that text box and save the settings. (Please DON'T type these lines yourself because you might introduce some spaces that will break the functionality)



If you create a new post now, it shows you clearly where to type the summary and where to add the rest of the post. It is important to make sure that the /span tag above is at the end of the post. To ensure this, use Edit Html tab instead of Compose tab while typing the post. After typing, you can go to compose mode and change fonts/colors etc. Please note that you could also divide some (or all) of your old posts into summary and full post by editing them. The "Read more" link will appear only for the posts that have been divided like this.

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